Sulfonamidsubstituerte benzopyranderivater, fremgangsmÕter for deres fremstilling, deres anvendelse som medikament samt farmas°ytiske preparater inneholdende forbindelsene

摘要

4-Sulphonamido-benzopyran derivatives (I) are new. 4-Sulphonamido-benzopyran derivatives of formula (I) and their salts are new: R1, R2 = H, CF3, C2F5, C3F7, alkyl, or phenyl optionally mono- or disubstituted; or R1 + R2 = alkylene; R3 = R10-Cn-H2n-N(R11)- or R10-CnH2n- in which 1 CH2 is optionally replaced; R4 = R13-CrH2r in which 1 CH2 is optionally replaced; or R3 + R4 = alkylene with 1 CH2 optionally replaced; n = 1-10; r = 1-20; R10 = H, Me, cycloalkyl, CF3, C2F5, or C3F7; R11 = H or alkyl; or R10 + R11 = a bond when n is at least 3; R13 = Me, CF3, C2F5, C3F7, cycloalkyl, NR15R16, or phenyl or N-containing heterocyclyl (both optionally mono- or disubstituted); R15, R16 = tetra- or pentamethylene in which 1 CH2 is optionally replaced); R5 = Y-CsH2s-R 18 or phenyl (optionally mono- or disubstituted); Y = O, S or NR10c; R10c = H or alkyl; s = 1-8; R18 = H, CF3, C2F5, C3F7, cycloalkyl, COOR21, NR15aR16a, N-containing heterocyclyl, or phenyl or thienyl (both optionally mono- or disubstituted); or R15a + R16a = tetra- or pentamethylene in which 1 CH2 is optionally replaced); R21 = H or alkyl; R6 = OR10d or OCOR10d B = H; or R6 + B = a bond; R10d = H or alkyl. The full definitions are given in the DEFINITIONS (Full Definitions) Field. Independent claims are also included for: (1) preparation of (I); (2) pharmaceutical compositions containing (I) and a beta-blocker.