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V. defective recombinant adenovirus, procariotic and bifunctional plasmides, procariotic cell, use of a defective recombinant virus, and, pharmaceutical composition
V. defective recombinant adenovirus, procariotic and bifunctional plasmides, procariotic cell, use of a defective recombinant virus, and, pharmaceutical composition
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机译:V.缺陷重组腺病毒,原核和双功能质粒,原细胞,缺陷重组病毒的用途以及药物组合物
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摘要
The invention concerns a defective recombinant virus and preferably an adenovirus characterised in that it comprises at least two nucleic acids coding for distinct enzymes, proteins and/or co-factors involved in the reverse transfer of cholesterol, said nucleic acids being operationally bound to a transcriptional promoter and mutually separated by a sequence coding for an internal entry site of the IRES ribosome. The invention further concerns plasmid constructs useful for preparing these adenovirus, and cells transformed by these plasmids or adenovirus and pharmaceutical compositions containing said adenovirus.
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