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METHODS AND COMPOSITIONS USEFUL IN INHIBITING ANGIOGENESIS IN WHICH ALPHAVBETA5 ACTS AS INTERMEDIARY
METHODS AND COMPOSITIONS USEFUL IN INHIBITING ANGIOGENESIS IN WHICH ALPHAVBETA5 ACTS AS INTERMEDIARY
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机译:抑制α5中间体作为血管生成的方法和组合物
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摘要
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin alpha v beta 5 antagonists. The alpha v beta 5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor- alpha and epidermal growth factor. Inhibition of alpha v beta 5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing alpha v beta 5 antagonists.
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