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PREPARATION PROCESS OF STABILIZED DRY CHEMICAL COMPOSITIONS CONTAINING A SOLUBLE ACID ADDING SALT IN WATER OF A LOW SOLUABLE BASIC COMPOUND, AND OF INCREASING THE INSENSIBILITY OF A GRANULATION PROCEDURE
PREPARATION PROCESS OF STABILIZED DRY CHEMICAL COMPOSITIONS CONTAINING A SOLUBLE ACID ADDING SALT IN WATER OF A LOW SOLUABLE BASIC COMPOUND, AND OF INCREASING THE INSENSIBILITY OF A GRANULATION PROCEDURE
Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble ( 2mg/ml) alkaline stabilizer. The dry composition is relatively more stable than one not containing the water soluble alkaline stabilizer, especially after a high temperature granulation process. The process for preparing the dry composition is also more "rugged" with the added water soluble alkaline stabilizer.
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