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SOLID ORAL ADMINISTRATION FORMS CONTAINING IFOSFAMIDE, AND PROCESS FOR THEIR PREPARATION
SOLID ORAL ADMINISTRATION FORMS CONTAINING IFOSFAMIDE, AND PROCESS FOR THEIR PREPARATION
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机译:包含IFOSM酰胺的固体口服给药剂型及其制备方法
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摘要
Solid oral ifosfamide preparations in the form of capsules, where the capsule composition essentially consists of the active agent ifosfamide and microcrystalline cellulose, and optionally a flow regulator and antiadhesive agent, whilst one part by weight of ifosfamide is added with 0.2 - 4 parts by weight of the microcrystalline cellulose and 0.001 - 0.1 parts by weight of the flow regulator and antiadhesion agent. There is further disclosed a process for the preparation of the said solid ifosfamide preparations which is commenced by mixing ifosfamide and the microcrystalline cellulose, and optionally a smaller amount of the flow regulator and antiadhesion agent, in accordance with the stated ratios, at 15 - 30 degrees Celsius; and the homogenous mixture thus obtained is filled into the capsules; thus obtained capsules are optionally coated by an appropriate coating.
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