AROMATIC-LINKED POLYAMINE MACROCYCLIC COMPOUNDS WITH ANTI-HIV ACTIVITY

摘要

LINKED CYCLIC POLYAMINES OF FORMULA Z - R - A – R` - Y WHERE Z AND Y ARE EACH CYCLIC POLYAMINE MOIETIES, A IS AN AROMATIC OR HETEROAROMATIC MOIETY, AND R AND R ARE EACH AN ALKYLENE CHAIN OR HETERATOM-CONTAINING CHAIN, SHOW HIGH ACTIVITY AGAINST HIV AND LOW TOXICITY, IN IN VITRO TESTS. NOVEL COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS ARE CLAIMED.