PDE TV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES

摘要

The present invention concerns 2-cyanoiminoimidazole derivatives having formula (I) the N-oxide forms, the pharmaceuticallyacceptable addition salts and the stereochemically isomeric forms thereof, wherein R[err] and R[err] each independently are hydrogen; C[err]alkyl;difluoromethyl; trifluoromethyl; C[err]cycloakyl; a saturated 5-, 6- or 7-membered heterocycle containing one or two heteroatomsselected from oxygen, sulfur or nitrogen; indanyl; 6,7-dihydro-5H-cyclopentapyridinyl; bicyclo[2,2,1]-2-heptenyl; bicyclo[2.2.1]heptanyl;C[err]-alkylsulfonyl; arylsulfonyl; or substituted C[err]alkyl; R[err] is hydrogen, halo or C[err]alkyloxy; R[err] is hydrogen; halo; C[err]alkyl;trifluoromethyl; -C[err]cycloalkyl; carboxyl; C[err]alkyloxycarbonyl; C[err]cycloalkylaminocarbonyl; aryl; Het[err]; or substituted C[err]alkyl; orR[err] is -O-R[err] or -NH-R[err]; R[err] is hydrogen, halo, hydroxy, C[err]alkyl or C[err]alkyloxy; R[err] is a hydrogen or C[err]alkyl; or R[err] and R[err], or R[err] andR[err] taken together may form a bivalent radical; -A-B- is -CR[err]-CR[err]- or -CHR[err]-CHR[err]-; L is hydrogen; C[err]alkyl; C[err]alkylcarbonyl;C[err]alkyloxycarbonyl; substituted C[err]alkyl; C[err]alkenyl; substituted C[err]alkenyl; piperidinyl; substituted piperidinyl; C[err]alkylsulfonyl orarylsulfonyl; having PDE IV and cytokine inhibiting activity. The invention also relates to processes for preparing the compounds offormula (I) and pharmaceutical compositions thereof.