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11 BETA-BENZALDOXIM-9 ALPHA, 10 ALPHA-EPOXY-ESTR-4-EN DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
11 BETA-BENZALDOXIM-9 ALPHA, 10 ALPHA-EPOXY-ESTR-4-EN DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
New 11 beta -benzaldoxim-9 alpha ,10 alpha -epoxy-estr-4-ene derivatives (I) and their salts are prepared by oxidation of the corresponding unsaturated compound (II). 11 beta -Benzaldoxim-9 alpha ,10 alpha -epoxy-estr-4-ene derivatives of formula (I) and their salts are new. R1 = H or 1-6C alkyl; R2 = H, 1-10C alkyl, aryl, aralkyl, alkylaryl, acyl, CONHR4 or COOR4; R4 = H, or 1-10C alkyl, aryl, aralkyl or alkylaryl; R3 = H, 1-10C alkyl, aryl, aralkyl or alkylaryl, (CH2)nCH2Y, OR5, (CH2)m-CH=CH(CH2)nR6 or (CH2)o-C(CR7; n = 0-2; Y = F, Cl, Br, I, CN, N3, rhodano, OR5 or SR5; R5 = H, 1-10C alkyl, aryl, aralkyl, alkylaryl or a 1-10C acyl group (COR5); m = 0-3; R6 = H, OH, 1-10C alkyl, aryl, aralkyl, alkylaryl, alkoxy or acyloxy; o = 0-2; R7 = H, F, Cl, Br, I, or 1-10C alkyl, aryl, aralkyl, alkylaryl or acyl; Z' = H, 1-10C alkyl, aryl, aralkyl, alkylaryl or acyl, or CONHR4 or COOR4 (in Z', R4 has the meanings given above, but may also be an alkali or alkaline earth metal atom). An Independent claim is also included for preparation of (I).
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机译：通过氧化相应的不饱和化合物（II）来制备新的11个β-苯并二恶英-9α，10α-环氧-雌烯-4-烯衍生物（I）及其盐。式（I）的11个β-苯甲醛肟-9α，10α-环氧-雌烯-4-烯衍生物及其盐是新的。 R 1 ＝ H或1-6C烷基; R 2 ＝ H，1-10C烷基，芳基，芳烷基，烷基芳基，酰基，CONHR 4或COOR 4; R 4 ＝ H，或1-10C的烷基，芳基，芳烷基或烷基芳基; R 3 ＝ H，1-10C烷基，芳基，芳烷基或烷基芳基，（CH 2）n CH 2 Y，OR 5，（CH 2）m -CH ＝ CH（CH 2）n R 6或（CH 2）o C（CR <7>; n = 0-2; Y = F，Cl，Br，I，CN，N3，罗丹奴，OR 5或SR 5; R 5 = H，1-10C烷基，芳基，芳烷基，烷基芳基或1-10C酰基（COR 5）; m ＝ 0-3; R 6 ＝ H，OH，1-10C烷基，芳基，芳烷基，烷基芳基，烷氧基或酰氧基; o ＝ 0 -2; R 7 ＝ H，F，Cl，Br，I或1-10C烷基，芳基，芳烷基，烷基芳基或酰基; Z'＝ H，1-10C烷基，芳基，芳烷基，烷基芳基或酰基，或CONHR 4或COOR 4（在Z'中，R 4具有以上给出的含义，但也可以是碱金属或碱土金属原子）。（I）的制备也包括独立权利要求。 。
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