PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE AND SOLVATES USEFUL FOR THE ISOLATION AND PURIFICATION OF QUINAPRIL CHLORHYDRATE.

摘要

PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE AND SOLVATES USEFUL FOR THE ISOLATION AND PURIFICATION OF QUINAPRIL CHLORHYDRATE. THE PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE (I) INCLUDES THE STAGES OF: A) HYDROGENOLYSIS OF BENZYLIC ESTER OF QUINAPRIL (II) BY TREATMENT IN A SOLUTION OF ALCOHOLIC HYDROCHLORIDE, OR WITH A CHLORID HYDROGEN SOLUTION. B) WITHDRAWAL OF THE SOLVENT; C) ADDITION OF TOLUENE TO PRECIPITATE QUINAPRIL CHLORHYDRATE AS A TOLUENE SOLVATE; D) TREATMENT OF SUCH SOLVATE WITH A CLASS 3 SOLVENT FORMING A QUINAPRIL CHLORHYDRATE SOLVATE WHICH CAN BE REMOVED BY DRYING WITHOUT DEGRADING; AND E) DRYING THE SOLVATE OF STAGE D) TO YIELD (I). THESE SOLVATES ARE USEFUL FOR ISOLATING AND PURIFYING (I), AN ANTI-HYPERTENSIVE AGENT.