Method for determining the residual moisture during secondary desiccation in a lyophilization process.

摘要

The invention relates to a process for the determination of moisture during drying RESIDUAL FINAL IN A PROCESS freeze drying; FOR OBTAINING RESIDUAL MOISTURE DRYING without interrupting the process, it proposed that the desorption rate during the final drying is measured at predetermined time intervals (eg 10 min.). A COMPUTER CALCULATED WITH TWO OR MORE MEASURED VALUES, TIME IN WHICH reach the desorption rate (ZERO RATE Desorption) to amend MARGINAL VALUE ONLY IN A RESIDUAL MOISTURE DESIRED. RESIDUAL MOISTURE FOR is determined by COMPUTER MAKING A TEMPORARY desorption rate integration from ZERO TO THE TIME OF MEASUREMENT.