PEPTIDIC PROINSULIN COMPOUNDS FOR DETECTING AND TREATING TYPE I DIABETES.

摘要

PROINSULIN PEPTIDE COMPOUNDS, WHICH MODULATE THE IMMUNOLOGICAL RESPONSE MEDIATED BY T-CELLS, OF TYPE I DIABETIC SUBJECTS, ARE DESCRIBED. BY PEPTIDE C OF PROINSULIN. PHARMACEUTICAL COMPOSITIONS, INCLUDING THESE PROINSULIN PEPTIDE COMPOUNDS, ARE ALSO DESCRIBED. THE IMMUNOLOGICAL RESPONSE INDUCED BY A PROINSULIN PEPTIDE COMPOUND, MAY BE USED AS AN INDICATOR OF TYPE I DIABETES IN A SUBJECT. ACCORDINGLY, THE INVENTION PROVIDES DIAGNOSTIC TESTS FOR TYPE I DIABETES, USING THESE COMPOUNDS. ALSO INCLUDED METHODS FOR INHIBITING THE DEVELOPMENT OR PROGRESSION OF TYPE I DIABETES IN A SUBJECT, THROUGH THE ADMINISTRATION OF A PROINSULIN PEPTIDE COMPOUND.