USE OF CARBAZOLE COMPOUNDS FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF CONGESTIVE HEART FAILURE.

摘要

A TREATMENT METHOD USING A COMPOUND OF FORMULA (I), WHERE R {SUB, 1} IS HYDROGEN, LOW MOLECULAR WEIGHT ALCANOYL OF UP TO 6 ATOMES OF CARBON OR AROYL SELECTED BETWEEN BENZOIL AND NAFTOYL; R {SUB, 2} IS HYDROGEN, RENT OF LOW MOLECULAR WEIGHT OF UP TO 6 ATOMS OF CARBON OR ARYLALKYL SELECTED BETWEEN BENCILO, FENILETILO AND FENILPROPILO, R {SUB, 3} IS HYDROGEN OR ALKYL OF BAJO PESO ; R {SUB, 4} IS HYDROGEN OR LOW ALKYL MOLECULAR WEIGHT OF UP TO 6 CARBON ATOMS, OR WHEN X IS OXYGEN, R {SUB, 4} TOGETHER WITH R {SUB, 5} MAY REPRESENT IS A LINK OF VALENCIA, SELECT STARTING FROM PHENYL, NAPHTHYL, INDANIL, AND TETRAHYDRONAFTHYL; R {SUB, 5} AND R {SUB, 6} ARE SELECTED INDIVIDUALLY FROM HYDROGEN, FLUORINE, CHLORINE, BROMINE, HYDROXYL, LOW MOLECULAR WEIGHT ALKYL UP TO 6 CARBON ATOMO, ONE NH GROUP {SUB, 2} -, LOW MOLECULAR WEIGHT ALCOXY OF UP TO 6 CARBON ATOMS, BENCILOXI, LOW MOLECULAR WEIGHT ALKYLTH OF UP TO 6 CARBON ATOMS, LOW MOLECULAR WEIGHT ALKYL SULFONYL, UP TO 6 CARBON ATOMS; OR R {SUB, 5} AND R {SUB, 6} TOGETHER REPRESENT METHYLENDIOXI; OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PREFERABLY CARVEDILOL, ALONE OR IN COMBINATION WITH ONE OR MORE DIFFERENT THERAPEUTICAL AGENTS, BEING SUCH SELECTED INSTITUTES, LAUTICAL DISEASES, DIUREIDOS AND DIUREIDOS CONGESTIVE (CHF) IN MAMMALS, ESPECIALLY IN HUMANS.