5-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives of formula (I) wherein eachof R and R1, being the same or different, is hydrogen, halogen, hydroxy,trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4 wherein R4 is C1-C6 alkyl, -N(R5R6) in which eachof R5 and R6 is, independently, hydrogen, C1-C6 alkyl, formyl or C2-C6 acyl;R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, benzyl, phenyl; R3 is hydrogen,hydroxy, C1-C6 alkyl, C1-C6 alkoxy, benzyl, phenyl or a group -N(R7R8) inwhich each of R7 and R8 is, independently, hydrogen, C1-C4 alkyl, benzyl,phenyl, or one of R7 and R8 is hydrogen and the other is COR9 wherein R9 ishydrogen, C1-C4 alkyl, C1-C4 alkoxy, phenyl or a group -N(R10R11) in which R10and R11 are, each independently, hydrogen or C1-C4 alkyl or, taken together,R2 and R3 form a carbocyclic C3-C6 ring; and pharmaceutically acceptable saltsthereof have kynurenine-3-hydroxylase enzyme inhibitory activity.
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