PCT No. PCT/EP98/04032 Sec. 371 Date Dec. 30, 1999 Sec. 102(e) Date Dec. 30, 1999 PCT Filed Jun. 25, 1998 PCT Pub. No. WO99/02506 PCT Pub. Date Jan. 21, 19995-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives of formula (I) wherein each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4 wherein R4 is C1-C6 alkyl, -N(R5R6) in which each of R5 and R6 is, independently, hydrogen, C1-C6 alkyl, formyl or C2-C6 acyl; R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, benzyl, phenyl; R3 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, benzyl, phenyl or a group -N(R7R8) in which each of R7 and R8 is, independently, hydrogen, C1-C4 alkyl, benzyl, phenyl, or one of R7 and R8 is hydrogen and the other is COR9 wherein R9 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, phenyl or a group -N(R10R11) in which R10 and R11 are, each independently, hydrogen or C1-C4 alkyl or, taken together, R2 and R3 form a carbocyclic C3-C6 ring; and pharmaceutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.
展开▼
