首页> 外国专利> DOCUMENTATION MEANS FOR REPERTOIRES OF NKR IMMUNORECEPTORS AND/OR ACTIVATORY OR NON-INHIBITORY IMMUNORECEPTOR COUNTERPARTS OF NKR IMMUNORECEPTORS

DOCUMENTATION MEANS FOR REPERTOIRES OF NKR IMMUNORECEPTORS AND/OR ACTIVATORY OR NON-INHIBITORY IMMUNORECEPTOR COUNTERPARTS OF NKR IMMUNORECEPTORS

机译:NKR免疫受体库和/或NKR免疫受体激活性或非抑制性免疫受体配伍的文献资料

摘要

The invention relates to an in vitro method of documenting a repertoire of NKR immunoreceptor (s) and / or NKR counterparts, comprising (i) the use of at least one pair of 3 'and 5' oligonucleotides capable of to hybridize to an NKR target receptor, or NKR counterpart, and not to hybridize to a functional counterpart receptor for this target receptor; (ii) bringing this pair of 3 'and 5' oligonucleotides into contact with the DNA or cDNA of a sample to be studied; and (iii) the detection of the hybrids possibly formed. The invention also relates to the biological applications of this method, in particular screening of a bank of organs, tissues, cells with a view to transplants, and to kits for its implementation.
机译:本发明涉及证明NKR免疫受体和/或NKR对应物库的体外方法,包括(i)使用至少一对能够与NKR靶标杂交的3'和5'寡核苷酸受体或NKR对应物,并且不与该目标受体的功能性对应物受体杂交; (ii)使这对3'和5'寡核苷酸与待研究样品的DNA或cDNA接触; (iii)检测可能形成的杂种。本发明还涉及该方法的生物学应用,特别是针对移植的器官,组织,细胞库的筛选,以及用于实施该试剂盒的试剂盒。

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