ACYLPHOSPHATES AND ACYLPHOSPHONATES AS .BETA.-LACTAMASE AND DD-PEPTIDASE INHIBITORS

摘要

The invention provides novel .beta.-lactamase inhibitors, which arestructurally unrelated to the natural product and semi-synthetic .beta.-lactamase inhibitors presently available, and which do not possess .beta.-lactam pharmacophore. These new inhibitors are fully synthetic, allowing readyaccess to a wide variety of structurally related analogs. Certain embodimentsof these new inhibitors also bind bacterial DD-peptidases, thus potentiallyacting both as .beta.-lactamase inhibitors and as antibiotics.