The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These "MOPs" (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are alpha-class hypoxia-inducible factors. Several other of the MOPs of the invention are involved in circadian signal transduction.
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