首页>
外国专利>
Hexadecasaccharide-protein conjugate vaccine for (shigella dysenteriae) type
Hexadecasaccharide-protein conjugate vaccine for (shigella dysenteriae) type
展开▼
机译:痢疾志贺氏菌型十六糖-蛋白质结合疫苗
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention pertains to isolated natural, modified natural or synthetic oligo- or polysaccharides which have [3)- alpha -L-Rhap-(1}2)- alpha -D-Galp-(1}3)- alpha -D-GlcpNAc-(1}3)- alpha -L-Rhap-(1}]n subunits and which are structurally related to and/or antigenically similar to an antigenic determinant of the O-specific polysaccharide of Shigella dysenteriae type 1. The oligo- or polysaccharides may be conjugated to a carrier to form conjugates. These oligo- or polysaccharides and conjugates thereof are immunogenic and elicit serum antibodies that are bactericidal or bacteriostatic against Shigella dysenteriae, in particular Shigella dysenteriae type 1, and are useful in the prevention and treatment of shigellosis. These oligo- or polysaccharides and conjugates thereof, and the antibodies which they elicit, are also useful for diagnosing shigellosis caused by Shigella dysentariae type 1.
展开▼