Chapter 14 Synthesis of Carbohydrate Antigens Related to Shigella dysenteriae Type 1 and of Their Protein Conjugates

摘要

Shigella dysenteriae type 1 is a major cause of dysentery worldwide but there is no licensed vaccine against these bacteria. The lipopolysaccharide of S. dysenteriae type 1 is both an essssential virulence factor and a protective antigen. We describe synthesis of oligosaccharides corresponding to the repeating subunits of the O-specific polysaccharide followed by an efficient method for their covalent binding to the protein carrier, in order to obtain a well defined synthetic glycoconjugate vaccine.