APPLICATION OF HELIX-RANDOM CHAIN THERMODYNAMICS TO NUCLEIC ACID ANALYSIS

摘要

The present invention relates generally to the field of genetics and nucleic acid research and, more particularly, to the detection of mismatches or differences between nucleotide sequences, to the detection of mutations, to the detection and evaluation of single and multiple nucleotide polymorphisms, and to the genotyping of cells, tissues or individuals. The methods are based on the effects of these mismatches or differences on helix-random chain thermodynamics.