METHOD OF TREATING DISORDERS CHARACTERIZED BY OVEREXPRESSION OF CYTIDINE DEAMINASE OR DEOXYCYTIDINE DEAMINASE

摘要

An agent of the chemical formula C7N3H8O2R1R2XX1, wherein X and X1 are each independently C or N but not simultaneously, R1 is lower alkyl, alkenyl or alkynyl, halogen or haloalkyl, and R2 is H, -N3 -OH, amino or halogen; or pharmaceutically acceptable salts thereof. A method of treating a disorder associated with the overexpression of cytidine deaminase or deoxycytidine deaminase comprises administering to a subject in need of the treatment a compound of the chemical formula wherein X and X1 are each independently C or N; R1 is lower alkyl, lower alkenyl, lower alkynyl, halogen, or haloalkyl; and R2 H, -N3, -OH, amino, or halogen; or a pharmaceutically acceptable salt thereof in an amount effective to treat the disorder. Pharmaceutical formulations useful in the method of the present invention are also disclosed.