METHODS FOR IDENTIFYING A RISK TO UCP2 AND UCP3 GENE VARIANT-RELATED AFFLICTIONS AND COMPOSITIONS THEREOF

摘要

The present invention provides a method for identifying a subject having a risk of developing obesity and/or diabetes, comprising detecting the presence of a single nucleotide polymorphism (SNP) in a nucleic acid encoding an uncoupling protein 2 or an uncoupling protein 3 from the subject, wherein the presence of the SNP is correlated with obesity and/or diabetes, thereby identifying the subject as having a risk of developing obesity and/or diabetes. The present invention also provides a method for identifying a subject having a risk of developing obesity and/or diabetes, comprising detecting the presence of an amino acid polymorphism in an uncoupling protein 2 or 3 from the subject, wherein the presence of the amino acid polymorphism is correlated with obesity and/or diabetes, thereby identifying the subject as having a risk of developing obesity and/or diabetes. The present invention also provides a method for identifying a subject having a risk of developing obesity and/or diabetes, comprising contacting a sample from the subject with an antibody to an antigen of an altered UCP2 or UCP3 protein, detecting the binding of the antibody with the antigen, wherein binding of antigen to the antibody indicates the presence of the altered UCP2 or UCP3 in the sample and wherein the presence of the altered UCP2 or UCP3 in the sample indicates a risk for developing obesity and/or diabetes, thereby identifying a subject having a risk of developing obesity and/or diabetes.