COMPOSITIONS AND METHODS FOR CONTROLLING BRCA1-MEDIATED P53-DEPENDENT AND -INDEPENDENT REGULATION OF TRANSCRIPTION

摘要

It has been discovered that BRCA1 mediates transcriptional activation of p21 and other tumor suppressor genes in a p53-dependent and p53-independent manner. Assays and compositions for identifying compounds that enhance or repress cellular proliferation via these newly-discovered BRCA1-mediated pathways are disclosed. Diagnostic methods and methods of controlling cell proliferation by altering the pathways are also disclosed.