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Use of decorin or biglycan for the manufacture of a medicament in the treatment of diabetes-associated pathology
Use of decorin or biglycan for the manufacture of a medicament in the treatment of diabetes-associated pathology
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机译:装饰蛋白或双糖链蛋白聚糖在制备与糖尿病相关的病理学疾病的药物中的用途
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摘要
The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor beta (TGF- beta ) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. Pathologies which can be so treated include the various fibrotic diseases such as fibrotic cancer, fibrosis of the lungs, arteriosclerosis, post myocardial infarction, cardiac fibrosis, post-angioplasty restenosis, renal interstitial fibrosis, scarring and diabetic nephropathy. The present invention further provides methods for treating diabetes and pharmaceutical compositions useful in such methods.
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