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MODULATION OF VASCULAR CELL ADHESION MOLECULE EXPRESSION THROUGH NOVEL OLIGONUCLEOTIDE INTERACTIONS
MODULATION OF VASCULAR CELL ADHESION MOLECULE EXPRESSION THROUGH NOVEL OLIGONUCLEOTIDE INTERACTIONS
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机译:新型寡核苷酸相互作用对血管黏附分子表达的调控
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摘要
Genes coding for vascular cell adhesion molecules, particularly VCAM-1, are modulated through interaction of oligonucleotides with transcriptional regulatory factors which bind to the genes. Specific and effective oligonucleotides are provided which interact with the transcriptional regulatory factors to diminish their interaction with the genes and downregulate their function. Multi-modal oligonucleotides are also provided which interact both with a transcriptional regulatory factor and with another aspect of gene function.
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