UNCHARGED MORPHOLINO-BASED POLYMERS HAVING ACHIRAL INTERSUBUNIT LINKAGES

摘要

Disclosed is a polymer composition consisting of a morpholino subunit structure linked together by uncharged achiral bonds. These bonds connect one to three atoms long, one subunit of morpholino nitrogen, to the 5 ''exocyclic carbon of another adjacent subunit. Each subunit contains a furan or pyrimidine base pairing portion that effectively binds to a specific base or base pair of the target polynucleotide by hydrogen bonding.