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Dry thin film formulation of mucoadhesive polymer gel and its preparation method
Dry thin film formulation of mucoadhesive polymer gel and its preparation method
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机译:粘膜粘附性聚合物凝胶的干薄膜配方及其制备方法
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摘要
The present invention relates to a thin film formulation prepared by making a mucoadhesive polymer in a gel state and then drying the same, and a method for preparing the same, which comprises preparing a solution containing 0.0001 to 20 wt% of a drug, 0.5 to 50 wt% of polyethylene oxide, 0.1 to 15 wt% of a plasticizer, And a purified thin film formulation of a mucopolysaccharide gel containing purified water, and a multi-layer drying method in which a polymer layer swellable or slowly dissolving in a body fluid is further laminated on the dried thin film of the mucopolysorbable polymer gel, Thin film formulation.;The thin film formulation according to the present invention is not tacky in a dry state, but is rapidly gelled by moisture and is restored to its mucosal tackiness. Therefore, when applied to an oral mucous membrane, the drug is rapidly adhered to a drug application site, It is possible to minimize the foreign body sensation of the user.
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