Mouse monoclonal antibody against surface antigen free-S 1 of hepatitis B virus, hybridoma cell line producing the same, and method for producing the same

摘要

The present invention relates to a monoclonal antibody that binds to a surface antigen pre-S1 (pre-S1) of hepatitis B virus (HBV), a hybridoma cell line that produces the antibody, and a method of producing the same. Specifically, the present invention relates to mouse monoclonal antibodies that specifically recognize the 21-28 amino acid containing epitope of HBV surface antigen pre-S1, which can neutralize various subtypes and mutant HBV, thereby preventing HBV infection It can be widely used for treatment.