Process for the preparation of terbutaline enantiomer from terbutaline racemate

摘要

The present invention relates to a process for preparing a terbutaline enantiomer from terbutaline racemate. Specifically, the process comprises the steps of 1) adding an optical isomerization reagent MBIC to terbutaline racemate to obtain a ()-diastereomer step; 2) separating the (+)-diastereomer mixture into a (+), (-)-diester stereomer using a column chromatograph using an ODS stationary phase; 3) hydrolyzing the stereomer at the separated (+) and (-)-dies to obtain an enantiomer, and obtaining terbutaline enantiomer in high purity compared with the conventional asymmetric synthesis method or chiral column chromatography And can also be obtained economically.