首页> 外国专利> Racemate and R-enantiomer of 2-5-(4-fluorophenyl)-3-pyridyl methylaminomethyl chroman, process of its preparation and pharmaceutical preparations in which it is comprised

Racemate and R-enantiomer of 2-5-(4-fluorophenyl)-3-pyridyl methylaminomethyl chroman, process of its preparation and pharmaceutical preparations in which it is comprised

机译:2- [5-(4-氟苯基)-3-吡啶基甲基氨基甲基]苯并二氢吡喃的外消旋体和R-对映体,其制备方法和包含其的药物制剂

摘要

Racemate and R-enantiomer of 2-[5-(4-fluorophenyl)-3-pyridyl methylaminomethyl] chroman and physiologically acceptable salts thereof are prepared in such a manner that 3-(chloromethyl)-5-(4-fluoromethyl) pyridine is brought into reaction with 2-aminomethyl chroman and/or the obtained base is converted through the reaction with an acid to salts thereof. The racemate is suitable for preparing a pharmaceutical preparation intended for treating disorders of central nervous system such as anxiety states, depressions, Alzheimer?s disease, and schizophrenia.
机译:2- [5-(4-氟苯基)-3-吡啶基甲基氨基甲基]苯并二甲酸酯的消旋体和R-对映体及其生理上可接受的盐的制备方法是,使3-(氯甲基)-5-(4-氟甲基)吡啶为与2-氨基甲基苯并二氢吡喃和/或所获得的碱通过与酸反应转化为其盐。外消旋体适合于制备用于治疗中枢神经系统疾病,例如焦虑症,抑郁症,阿尔茨海默氏病和精神分裂症的药物制剂。

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