Substituted N-acyl-2-substituted-4-(benzimidazolyl-or imidazopyridinyl-substituted residue)-piperidine as a tachykinin antagonist

摘要

The present invention relates to compounds of the following general formula (I), the N-oxides thereof, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, the process for their preparation, the compositions containing them and their use as medicaments:;In this formula,;n is 0, 1 or 2;;m is 1 or 2, provided that when m is 2, n is 1;;X is a covalent bond or a group of the formula-O-,-S-, or-NR³-is a radical;;= Q = O or NR³ego;;R^OneAr^One, Or C_1-6Ar RTI ID = 0.0 ^OneC_1-6Alkyl or di (Ar^One) C_1-6Alkyl;;R²Ar², Ar²C_1-6Alkyl, Het or HetC_1-6Alkyl;;L is a benzimidazole or imidazopyridine derivative of the general formula (A) or (B);;Ar^OneIs optionally substituted phenyl;;Ar²Naphthalenyl; Or optionally substituted phenyl;;Het is an optionally substituted monocyclic or bicyclic heterocycle.