17-branched alkynyl- and 20-oxopregna-derivatives of vitamin D, their preparation and their pharmaceutical compositions

摘要

The 1-hydroxypregcarceropyrrole derivatives of formula (I) and their corresponding 5,6-trans adducts exhibit anti-progesterone activity and are useful as anti-neoplastic, antifibrotic, antiproliferative, immunosuppressive and / or anti-inflammatory agents . Wherein R ¹ is a hydroxyl group or a lower alkoxy group and R ² is an optionally hydroxylated or lower alkoxylated lower alkynyl or R ¹ is -C (R ^A ) (R ^B ) CH _{3 wherein} R ^A is optionally hydroxylated or lower alkoxylated lower alkynyl group and R ^B is a hydroxyl group or a lower alkoxy group, or R ^a and R ^B represents an a-oxo together, R ² is hydrogen, hydroxyl or lower alkoxy, And R ³ and R ⁴ are each a hydrogen atom.