Activators and methods for treating diseases associated with overexpression of cytidine deaminase or deoxycytidine deaminase

摘要

In a patient in need of treatment of a disease characterized by overexpression of cytidine deaminase or deoxycytidine deaminase, a method of treating said disease is disclosed. The method comprises reacting a compound of formula I:;(I);(Wherein X and X_OneAre each independently C or N;;R_OneIs a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halogen or a haloalkyl group; And;R₂Is H,-N₃,-OH, an amino group or a halogen);Or a pharmaceutically acceptable salt thereof, to the patient in an amount effective to treat the disease.;Pharmaceutical formulations useful in the methods of the present invention are also disclosed.