Stereoselective synthesis of beta-amino-alpha-hydroxy acids and equivalent oxazoline derivatives

摘要

The present invention is a method for synthesizing -amino--hydroxy acid and an equivalent oxazoline derivative from -amino acid. -A method for synthesizing an intermediate compound that can be used as a substrate for a palladium (0) catalyst with an amino acid as a starting material and then synthesizing an oxazoline derivative using an intramolecular cyclization reaction using a palladium (0) Unlike the method, it is applicable to all -amino acids and it is characterized by superior stereoselectivity in the synthesis of taxol side chain than the conventional method.