PREPARATION OF CEPHALOSPORIN ANTIBIOTIC USING SYN-ISOMER OF THIAZOLYL INTERMEDIATE

摘要

The present invention relates to 7-amino-3 [1-methyl-1-pyrrolidinio) methyl] cep-3-m-4-carboxylate 2- (2-aminothiazol-4-yl) -2- An aqueous solution acylation process for the preparation of cefepime dihydrochloride hydrate antibiotics substantially free of anti-isomers and Δ ² isomers, consisting of N-acylating with neo-isomers of methoxyimino acetyl chloride hydrochloride.