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PEPTIDE COMPOSITIONS FOR INHIBITION OF ANGIOTENSIN CONVERTING ENZYME AND PROCESS FOR THE PREPARATION THEREOF

机译:抑制血管紧张素转化酶的肽组合物及其制备方法

摘要

The present invention relates to a method for producing a peptide mixture with high inhibitory activity of Angiotensin Converting Enzyme (ACE) by enzymatic digestion and an angiotensin converting enzyme inhibitory peptide mixture prepared thereby.;According to the present invention, the protein is hydrolyzed by the promodal 278 (aspergillus-derived endopeptidase and papain), or the promodal 278 and promod 279 (aspergillus-derived exopeptidase) enzymes so that the degree of hydrolysis is 16 to 51%. An angiotensin converting enzyme inhibitory peptide mixture obtained by hydrolysis is provided.;According to the present invention, an angiotensin converting enzyme inhibitor peptide mixture can be obtained by hydrolyzing a protein substrate to have a range of degree of hydrolysis using a low concentration of hydrolase.
机译:本发明涉及一种通过酶消化制备具有高抑制活性的血管紧张素转化酶(ACE)的肽混合物的方法以及由此制备的血管紧张素转化酶抑制肽的混合物。前体278(来自曲霉属的内肽酶和木瓜蛋白酶),或前体278和promod 279(来自曲霉属的外肽酶)酶,因此水解度为16%至51%。提供了通过水解获得的血管紧张素转化酶抑制剂肽混合物。根据本发明,可以通过使用低浓度的水解酶将蛋白底物水解至具有一定程度的水解度而获得血管紧张素转化酶抑制剂肽混合物。

著录项

  • 公开/公告号KR100195984B1

    专利类型

  • 公开/公告日1999-06-15

    原文格式PDF

  • 申请/专利权人 NONG SHIM CO.LTD;

    申请/专利号KR19960000412

  • 发明设计人 신재익;남희섭;안창원;안상원;

    申请日1996-01-11

  • 分类号A61K38/01;

  • 国家 KR

  • 入库时间 2022-08-22 02:15:57

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