CELL-FREE ANTISTAPHYLOCOCCUS VACCINE FOR TREATMENT OF PATIENTS WITH CHRONIC STAPHYLOCOCCUS INFECTION

摘要

FIELD: medicine, vaccines. SUBSTANCE: invention relates to vaccine consisting of thermolabile and thermostable antigens providing high protective activity of a preparation. The latter is a cell-free antistaphylococcus vaccine involving thermolabile and thermostable protein-polysaccharide antigens from cellular wall of S. aurus, strains N 1991, 1986 exhibiting immunogenicity EД₅₀ = 20-100 mln. microbial cells, virulence ЛД₅₀ = 0.5-2.0 billion microbial cells, low content of protein A and weak allergenic activity. EFFECT: enhanced effectiveness of vaccine, low-reactive property. 7 tbl, 1 ex