DERIVATIVES OF POLYSUBSTITUTED 2-AMIDO-4-PHENYLTHIAZOLES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I) where Y means 3-quinolinyl group or 2-indolyl group of the formula (II) where R means hydrogen, acetyl group or group CH₂COOR being R means hydrogen or C₁-C₄-alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C₁-C₄-alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex