OPTICALLY ACTIVE BETA-AMINOALKIXYBORANE COMPLEX, METHOD OF ITS PREPARATION, OPTICALLY ACTIVE BETA-AMINO-ALCOHOL DERIVATIVE FOR PREPARATION OF AMINOALKOXYBORANE COMPLEX, AND METHODS OF COMPLEX- MEDIATED PREPARATION OF OPTICALLY ACTIVE ALCOHOLS

摘要

FIELD: organic synthesis. SUBSTANCE: optically active beta-aminoalkixyborane complexes with general formula I: (I) are provided, in which formula R¹ is C₁-C₃-alkyl and C₇-C₁₁-arylalkyl, R² is C₁-C₈-alkyl, C₃-C₇- cycloalkyl or C₇-C₁₁-arylalkyl, or R¹ and R² form (CH₂)_n in which n=3 or 4 and Ar is naphthyl, anthryl or phenanthryl which can be substituted by 1-3 substituents selected from the group including halogen, C₁-C₆-alkyl, C₆-C₁₀-aryl, and -alkoxy. Also provided is optically active beta-aminoalcohol derivatives with general formula II: R¹ (II), where R², R², n and Ar are the same as defined above on condition that, when Ar is naphthyl, C₁-C₈ is not R¹-alkyl or when Ar is phenanthryl, R² and (CH₂)₃ do not form . Methods of preparing compounds I, IV, VI-1 and VI-2 [ (IV), (VI-1), and (VI-2)] are as well provided. Compounds of invention give rise to higher asymmetrical yield and higher diastereoselectivity (higher sin- isomer formation) than standard borane complexes. These compound may also find use in pharmaceutics, in agriculture, or for cosmetics. EFFECT: facilitated asymmetrical syntheses. 7 cl, 2 dwg, 6 tbl, 4 ex