Reducing side effects or neutralizing action of carcinostatic or immunosuppressive agents, especially pyridine derivatives, using vitamin PP compounds, e.g. nicotinamide

摘要

Vitamin PP compounds (I) are used for reducing the side-effects and/or neutralizing the action of carcinostatic or immunosuppressive agents (II). The use of compounds (I) having vitamin PP activity is claimed as cytoprotective agents for preventing, reducing or eliminating the mild or acute side-effects and/or neutralizing the action of carcinostatic or immunosuppressive agents (II) (especially substituted pyridylalkanoic, pyridylalkenoic or pyridylalkynoic acid amides), in diagnostic, cytostatic or immunosuppressive chemotherapy, antiproliferative or metastasis formation inhibiting or preventing therapy or the control of immune reactions such as autoimmune disease. (II) is optionally used in combination with radiotherapy. An Independent claim is included for pharmaceutical compositions containing at least one of several specific classes of nicotinic acid or nicotinamide derivatives or analogs as (I) and at least one of a specific class of substituted pyridylalkanoic, pyridylalkenoic or pyridylalkynoic acid amides as (II), plus carriers and additives.