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order for the production of (s) (+) - 4, 4 '- (1 - methyl - 2 - ethandiyl) to (2.6 piperazindion
order for the production of (s) (+) - 4, 4 '- (1 - methyl - 2 - ethandiyl) to (2.6 piperazindion
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机译:生产(s)(+)-4、4'-(1-甲基-2-乙炔基)到(2.6哌嗪酮)的订单
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PCT No. PCT/GB92/01942 Sec. 371 Date Nov. 23, 1994 Sec. 102(e) Date Nov. 23, 1994 PCT Filed Oct. 22, 1992 PCT Pub. No. WO93/08172 PCT Pub. Date Apr. 29, 1993This invention provides a process for the preparing of (S) (+)-4,4'-(1-methyl-1,2-ethanediyl)-bis-(2,6-piperazinedione) (ICRF-187), by synthesizing a crude mixture comprising a 1,2-diaminopropane tetraacetic acid intermediate and byproducts; and then subjecting the tetraacetic acid intermediate, as part of the crude mixture, to ring formation in the presence of the byproducts, thereby producing ICRF-187 in commercially useful amounts.
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