Use of cells appropriate for the screening inhibitors of tubulin - carboxypeptidase and applications of these latter as anti - cancerous

摘要

The invention concerns the use of cells wherein the tubulin tyrosination-detyrosination cycle is modified, for screening and selecting inhibitors of the tubulin-carboxypeptidase, their use as anti-cancer agents and the screening method using said cells. Said cells, which over-produce tubulin-glu, are adapted for selecting or screening products inhibiting the tubulin-carboxypeptidase activity (TCP).