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Selecting substances for treating glucocorticoid-mediated inflammation or immune diseases using Tripterygium wilfordii Hook F extracts
Selecting substances for treating glucocorticoid-mediated inflammation or immune diseases using Tripterygium wilfordii Hook F extracts
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机译:雷公藤雷公藤Hook F提取物选择用于治疗糖皮质激素介导的炎症或免疫疾病的物质
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摘要
The present invention provides for the use of Tripterygium wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase- 2 induction and inflammatory processes such as the production of prostaglandin E.sub.2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.
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