USE OF TRIPTERYGIUM WILFORDII HOOK.F'S EXTRACTS FOR PREPARATION OF MEDICAMENTS FOR PREVENTING AND TREATING NERVOUS SYSTEM DISORDE RS

摘要

This invention relates to the use of one or more extracts of Tripterygium Wilfordii Hook.f for the preparation of medicaments for preventing and treating nervous system disorders, said Tripterygium Hook. f's extracts selected from: Triptolide, tripchloride, tripdiolide, triptriolide, 16-hydroxytriptolide, triptolidemol, triptolidenol, tripterine and wilfortrine. These tripterygium wilfordii' extracts have immunosuppressive activity, as well as have significant nutritional effect of dopaminergic (DA) neuron. It can stimulate the growth of mesenphalic nerve cells, and stimulate elongation of process of primary cultured cortical nerve cells, they can antagonized the injury effect of exogenous toxin, endogenous toxin and excitatory nerve toxin on the nerve cells, and have remarkable protection on cell survival.