Disinfectant dye removal from blood and blood fractions using a porous poly(vinyl alcohol-acetal) copolymer

摘要

A process for removing disinfectant dye such as methylene blue from blood, a liquid blood fraction or other perishable liquid to which disinfectant dye has been added. The process employs a filter of polyvinyl alcohol-acetal copolymer. This material shows exceptional avidity for disinfectant dyes, readily removing them from blood or blood fractions while having little or no effect on subsequent chemicals analysis of the treated material. The filter material is a porous matrix that releases no particles or fines into the blood product, and its white color readily shows the capture of the blue dye. Disinfectant dyes are used to extend the shelf life of platelet concentrates with the dyes being removed by a PVAA filter prior to transfusion into a patient. Also, triglycerides may also be removed from plasma or other solutions by passage through a porous matrix of poly(vinyl alcohol-acetal) copolymer.