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Nucleic acids encoding for non-infectious, replication-defective, self- assembling HIV-1 viral particles containing antigenic markers in the gag coding region
Nucleic acids encoding for non-infectious, replication-defective, self- assembling HIV-1 viral particles containing antigenic markers in the gag coding region
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机译:编码非传染性,复制缺陷型,自组装的HIV-1病毒颗粒的核酸,在gag编码区中包含抗原标记
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摘要
Non-infectious, retrovirus-like particles comprise an assembly of an env gene product, a pol gene product and a gag gene product contain an antigenic marker which is non-retroviral or non-HIV retroviral. In one embodiment, the marker comprises an amino acid sequence containing an epitope inserted into the gag gene product at an antigenically-active insertion site. In another embodiment, the marker comprises an antigenic anchor sequence operatively connected to the env gene product replacing endogenous anchoring function. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in in vivo administration including to humans and in diagnosis. The presence of the antigenic marker enables recognition that antiserum containing anti-retroviral antibodies has been generated by exposure to the non-infectious retrovirus-like particles by testing for antibodies specific to the antigenic marker.
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