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Transgenic mice expressing TSSV40 large T antigen
Transgenic mice expressing TSSV40 large T antigen
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机译:表达TSSV40大T抗原的转基因小鼠
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摘要
The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non- constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non- dividing state in tissue culture by activating expression of said sequence.
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