Method of producing aryl-substituted, amino-acylated phosphonic- acid derivatives with the aid of metal complexes of chiral, amphiphilic ligands

摘要

The invention is relates to a method of producing aryl- substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral amphiphilic ligands in that according to the invention &agr;-N-acyl-protected, &bgr;-substituted alkene phosphone derivatives are asymmetrically hydrogenated in the presence of a chiral rhodium catalyst in a solvent or a suspension. The use of the micelle- forming catalyst makes possible the hydrogenation of unsaturated phosphonic-acid derivatives in water with a high reaction rate with the obtainment of very good enantiomeric excesses.