Inhibition of bacterial binding by high-mannose oligosaccharides

摘要

The present invention describes a method for the treatment of gram- negative bacterial infections using high-mannose containing oligosaccharides. Specifically the use of Man.sub.9 (GlcNAc).sub.2 - hydrophobic glycopeptides (i.e. tyrosinamide) to block adhesion of the bacteria pili to the oligosaccharide of the host cells plasma membrane in infections of Enterobacter cloacae and other Enterobacter and gram- negative species.