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Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
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机译:非胰岛素受体酪氨酸激酶的酪氨酸激酶结构域的晶体
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摘要
Crystals of the tyrosine kinase domain of cytoplasmic tyrosine kinases and receptor tyrosine kinases that undergo ligand-mediated receptor dimerization are provided. In particular, crystals of a mutant of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FLGK), alone and in complex with a non-hydrolyzable adenosine triphosphate analogue, are provided. Also provided are the high resolution three dimensional structures of crystalline FLGK, both alone and in co-complex with the adenosine triphosphate analogue, as determined by X-ray diffraction.
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